Coexistence of chronic neutrophilic leukemia with multiple myeloma

Leuk Lymphoma. 2002 Mar;43(3):649-51. doi: 10.1080/10428190290012218.


A case report of simultaneous presentation of chronic neutrophilic leukemia and multiple myeloma (IgG kappa) in a 71-year-old male is described. The patient showed mature neutrophilic leukocytosis, hepatosplenomegaly, high neutrophil alkaline phosphatase score, hyperuricemia, neutrophils with toxic granulation and Döhle bodies, absence of Philadelphia chromosome and of the bcr-abl fusion gene. Moreover, a monoclonal IgG kappa paraproteinemia (36.93 g l(-1)) was detected. Bence-Jones proteinuria was 3.84 g l(-1). The bone marrow was grossly hypercellular with marked myeloid hyperplasia and aggregates of plasma cells. The patient died of severe bronchopneumonia after the transformation of chronic neutrophilic leukemia to acute myelomonocytic leukemia, 1.5 years following diagnosis.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aged
  • Blood Platelets / immunology
  • Blood Platelets / pathology
  • Fatal Outcome
  • Humans
  • Immunoglobulin G
  • Immunoglobulin kappa-Chains
  • Leukemia, Myelomonocytic, Acute / etiology
  • Leukemia, Neutrophilic, Chronic / complications*
  • Leukemia, Neutrophilic, Chronic / diagnosis
  • Leukemia, Neutrophilic, Chronic / pathology
  • Male
  • Multiple Myeloma / complications*
  • Multiple Myeloma / diagnosis
  • Multiple Myeloma / pathology


  • Immunoglobulin G
  • Immunoglobulin kappa-Chains