Functional analysis of the Erwinia herbicola tutB gene and its product

J Bacteriol. 2002 Jun;184(11):3135-41. doi: 10.1128/JB.184.11.3135-3141.2002.


The tutB gene, which lies just downstream of tpl, has been cloned from Erwinia herbicola, and its product was analyzed. Despite its high sequence similarity to tryptophan transporters, TutB was found to be a tyrosine-specific transporter. Tryptophan acted as a competitive inhibitor of tyrosine transport. Unlike the tryptophanase operon, the tpl and tutB genes do not constitute an operon.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Bacterial Proteins / genetics
  • Bacterial Proteins / physiology*
  • Biological Transport / drug effects
  • Cloning, Molecular
  • Erwinia / chemistry
  • Erwinia / genetics*
  • Escherichia coli / metabolism
  • Genes, Bacterial*
  • Genetic Vectors
  • Molecular Sequence Data
  • Operon
  • Sequence Alignment
  • Tryptophan / pharmacology
  • Tyrosine / metabolism


  • Bacterial Proteins
  • TutB protein, Pantoea agglomerans
  • Tyrosine
  • Tryptophan

Associated data

  • GENBANK/AF418596