doi: 10.1271/bbb.66.679.
Isolation and identification of a new bifidogenic growth stimulator produced by Propionibacterium freudenreichii ET-3
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- PMID: 12005071
- DOI: 10.1271/bbb.66.679
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Isolation and identification of a new bifidogenic growth stimulator produced by Propionibacterium freudenreichii ET-3
Biosci Biotechnol Biochem.
2002 Mar.
Free article
Abstract
We have found a new growth stimulator for bifidobacteria in the culture broth of Propionibacterium freudenreichii ET-3. The bifidogenic growth stimulator (BGS) was purified by Diaion HP-20 column chromatography and preparative HPLC. Spectroscopic methods including 1H-NMR, UV, and LC-ESI-MS experiments indicated that the chemical structure of the bifidogenic growth stimulator was 1,4-dihydroxy-2-naphthoic acid (DHNA). Approximately 10 mg/L of DHNA was found to be produced in the culture broth of P. freudenreichii ET-3.
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