A newly identified single nucleotide polymorphism in the promoter of the matrix metalloproteinase-1 gene

Mol Cell Probes. 2002 Feb;16(1):63-6. doi: 10.1006/mcpr.2001.0398.

Abstract

Matrix metalloproteinase-1 (MMP-1) is a member of the matrix metalloproteinase enzyme family that degrades components of the extracellular matrix. Recent studies have demonstrated several polymorphic sites in the promoter of the MMP-1 gene. A newly identified single nucleotide polymorphism (SNP) at position -519 in the promoter region of the MMP-1 gene is reported. This polymorphism consists in a guanine to adenine substitution. A linkage between polymorphisms -519A/G and -1607 1G/2G was also studied.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Binding Sites
  • Colorectal Neoplasms / genetics
  • Czech Republic
  • European Continental Ancestry Group
  • Female
  • Gene Frequency
  • Humans
  • Male
  • Matrix Metalloproteinase 1 / genetics*
  • Matrix Metalloproteinase 1 / metabolism
  • Middle Aged
  • Polymorphism, Single Nucleotide*
  • Promoter Regions, Genetic

Substances

  • Matrix Metalloproteinase 1