Gene expression: the close coupling of transcription and splicing

Curr Biol. 2002 Apr 30;12(9):R319-21. doi: 10.1016/s0960-9822(02)00829-1.

Abstract

Increasing evidence indicates that the transcriptional machinery can influence the efficiency of splicing as well as splice-site selection. Surprisingly, it has now been demonstrated that splicing components influence the efficiency of transcription. This mutual stimulation has important implications for the regulation of gene expression.

MeSH terms

  • Gene Expression Regulation*
  • RNA Polymerase II / metabolism
  • RNA Splicing*
  • Transcription, Genetic*

Substances

  • RNA Polymerase II