MAP kinase module: the Ksr connection

Curr Biol. 2002 Apr 30;12(9):R325-7. doi: 10.1016/s0960-9822(02)00831-x.

Abstract

Ksr has been genetically defined as a component of the Ras/MAP kinase pathway, but its role has been unclear. New studies now provide evidence that Ksr is important for signal transmission within the MAP kinase module, where it apparently acts as a location-regulated scaffold connecting MEK to Raf.

MeSH terms

  • Animals
  • MAP Kinase Kinase Kinase 1*
  • Mice
  • Mitogen-Activated Protein Kinases / metabolism*
  • Protein Kinases / metabolism*
  • Protein-Serine-Threonine Kinases / metabolism
  • Proto-Oncogene Proteins c-raf / metabolism
  • Signal Transduction*

Substances

  • Protein Kinases
  • KSR-1 protein kinase
  • Protein-Serine-Threonine Kinases
  • Proto-Oncogene Proteins c-raf
  • Mitogen-Activated Protein Kinases
  • MAP Kinase Kinase Kinase 1
  • Map3k1 protein, mouse