Predictors of nursing home admission and/or death in incident Alzheimer's disease and other dementia cases compared to controls: a population-based study

J Clin Epidemiol. 2002 May;55(5):462-8. doi: 10.1016/s0895-4356(01)00498-x.


This research elucidates the risk of institutional care and/or death of patients with Alzheimer's disease (AD) or other dementia (OD) compared with noncases. Community dwelling incident cases of AD (n = 240) or OD (n = 208) and age-matched noncases (n = 363) living in an enumerated population were included. The adjusted hazard ratio (HR) of being admitted to a nursing home compared with controls was 5.44 (95% confidence interval, CI: 3.68,8.05) for AD cases and 5.08 (95% CI: 3.38, 7.63) for OD cases. The adjusted RR of death compared to controls was 1.90 (95% CI: 1.36, 2.65) for AD cases and 2.27 (95% CI: 1.62, 3.18) for OD cases. This is the only population-based study in the U.S. documenting that AD/OD increases the risk of death independent of comorbid conditions. AD/OD patients have more comorbidities and are at greater risk of entering a nursing home than to die during the follow-up, compared with those without these diagnoses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / mortality*
  • Alzheimer Disease / therapy
  • Case-Control Studies
  • Comorbidity
  • Dementia / mortality
  • Dementia / therapy
  • Female
  • Geriatric Assessment*
  • Homes for the Aged / statistics & numerical data*
  • Humans
  • Institutionalization / statistics & numerical data*
  • Male
  • Nursing Homes / statistics & numerical data*
  • Prospective Studies
  • Risk Assessment*
  • Risk Factors
  • Wisconsin / epidemiology