Antrodia camphorata polysaccharides exhibit anti-hepatitis B virus effects

FEMS Microbiol Lett. 2002 Mar 19;209(1):63-7. doi: 10.1111/j.1574-6968.2002.tb11110.x.

Abstract

Polysaccharides were extracted from fruiting bodies and cultured mycelia from five Antrodia camphorata strains. Polysaccharide profiles of the five strains, as determined by high-performance anion-exchange chromatography, showed varying yields and composition of neutral sugars. A. camphorata fruiting bodies also had different polysaccharide patterns compared to the cultured mycelium. Analysis of 26-day-old mycelia showed that the neutral sugars galactose, glucose, mannose, and galactosamine were predominant. All mycelia polysaccharide preparations exhibited anti-hepatitis B virus activity. Polysaccharides from strain B86 at a concentration of 50 microg ml(-1) showed the highest level of anti-hepatitis B surface antigen effect, which was higher than alpha-interferon at a dosage of 1000 U ml(-1). Only strains B86 and 35398 had substantial anti-hepatitis B e antigen activities. None of the polysaccharides exhibited cytotoxic effects.

Publication types

  • Comparative Study

MeSH terms

  • Antiviral Agents / isolation & purification
  • Antiviral Agents / pharmacology*
  • Cell Line
  • Chromatography, High Pressure Liquid
  • Drug Evaluation, Preclinical
  • Hepatitis B Surface Antigens / analysis
  • Hepatitis B virus / drug effects*
  • Humans
  • Interferon alpha-2
  • Interferon-alpha / pharmacology
  • Polyporales / chemistry*
  • Polysaccharides / isolation & purification
  • Polysaccharides / pharmacology*
  • Recombinant Proteins

Substances

  • Antiviral Agents
  • Hepatitis B Surface Antigens
  • Interferon alpha-2
  • Interferon-alpha
  • Polysaccharides
  • Recombinant Proteins