RTS1-an eukaryotic terminator of replication

Int J Biochem Cell Biol. 2002 Sep;34(9):1031-4. doi: 10.1016/s1357-2725(02)00040-7.

Abstract

Eukaryotic replication termination generally occurs randomly in the region between two active origins. However, termination, or pausing of the replication forks has been observed at specific loci. Recently, a site-specific terminator of replication named RTS1 was shown to play an important role in mating-type switching in Schizosaccharomyces pombe. Mating-type switching in S. pombe relies on an imprinting event that chemically modifies one strand of the DNA at the mating-type locus mat1. This imprint, that is formed only when mat1 is replicated in a specific direction, marks the DNA for a rearrangement leading to mating-type switching. The RTS1 element ensures that mat1 is replicated in the correct direction for imprinting and initiation of the subsequent mating-type switching event. This is the first replication terminator shown to play a role in cellular differentiation.

Publication types

  • Review

MeSH terms

  • Animals
  • Base Sequence
  • DNA Replication / physiology*
  • DNA, Fungal / genetics
  • DNA, Fungal / metabolism
  • Genomic Imprinting
  • Humans
  • Molecular Sequence Data
  • Schizosaccharomyces / physiology*
  • Schizosaccharomyces pombe Proteins / metabolism*

Substances

  • DNA, Fungal
  • Schizosaccharomyces pombe Proteins