The catalytic asymmetric Mannich-type reactions in aqueous media

Shū Kobayashi; Tomoaki Hamada; Kei Manabe

doi:10.1021/ja026094p

The catalytic asymmetric Mannich-type reactions in aqueous media

J Am Chem Soc. 2002 May 22;124(20):5640-1. doi: 10.1021/ja026094p.

Authors

Shū Kobayashi¹, Tomoaki Hamada, Kei Manabe

Affiliation

¹ Graduate School of Pharmaceutical Sciences, The University of Tokyo, CREST, Japan.

PMID: 12010028
DOI: 10.1021/ja026094p

Abstract

The catalytic, diastereo- and enantioselective Mannich-type reaction of a hydrazono ester with silyl enol ethers in aqueous media has been successfully achieved with ZnF(2), a chiral diamine ligand, and trifluoromethanesulfonic acid.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amines / chemical synthesis*
Catalysis
Diamines / chemistry
Fluorides / chemistry
Ketones / chemical synthesis*
Water / chemistry
Zinc Compounds / chemistry

Substances

Amines
Diamines
Ketones
Zinc Compounds
Water
zinc fluoride
Fluorides