Effect of KAD-1229, a novel hypoglycaemic agent, on plasma glucose levels after meal load in type 2 diabetic rats

Clin Exp Pharmacol Physiol. May-Jun 2002;29(5-6):423-7. doi: 10.1046/j.1440-1681.2002.03682.x.

Abstract

1. The effects of KAD-1229 (a novel non-sulphonylurea agent), voglibose (an alpha-glucosidase inhibitor) and nateglinide (a non-sulphonylurea antihyperglycaemic agent) on hyperglycaemia induced by a meal load were assessed in diabetic rats. 2. KAD-1229 suppressed the increase in plasma glucose levels seen after a meal load and the area under the curve for plasma glucose levels (AUCglucose) up to 5 h after the meal load. 3. Voglibose also suppressed the increase in plasma glucose levels; however, a significant decrease in AUCglucose following voglibose was not observed. 4. Nateglinide suppressed the increase in plasma glucose levels at 30 min and 1 h after the meal load; however, plasma glucose levels was above control thereafter and the AUCglucose was not decreased. 5. The results indicate that KAD-1229 has an antihyperglycaemic effect and KAD-1229 is suggested to be a suitable agent for controlling post-prandial hyperglycaemia.

MeSH terms

  • Animals
  • Blood Glucose / metabolism*
  • Cyclohexanes / pharmacology
  • Diabetes Mellitus, Experimental / blood
  • Diabetes Mellitus, Experimental / drug therapy*
  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / drug therapy*
  • Food
  • Hypoglycemic Agents / pharmacology*
  • Indoles / pharmacology*
  • Inositol / analogs & derivatives*
  • Inositol / pharmacology
  • Isoindoles
  • Nateglinide
  • Phenylalanine / analogs & derivatives*
  • Phenylalanine / pharmacology
  • Postprandial Period*
  • Rats
  • Rats, Wistar
  • Species Specificity

Substances

  • Blood Glucose
  • Cyclohexanes
  • Hypoglycemic Agents
  • Indoles
  • Isoindoles
  • Nateglinide
  • Phenylalanine
  • Inositol
  • mitiglinide
  • voglibose