Circling mouse, a spontaneous mutant in the inner ear

Exp Anim. 2002 Apr;51(2):167-71. doi: 10.1538/expanim.51.167.


A spontaneous mutant was established in the ICR mouse strain. The affected mice became hyperactive at about 7 days of age, and then showed circling behavior. The body weight decreased significantly 2 weeks after birth, and developmental defects were revealed in the middle ear, cochlea, cochlear nerve, and semicircular canal areas. The mutation was inherited by an autosomal single recessive gene and is referred to as cir.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Behavior, Animal
  • Body Weight
  • Cochlea / abnormalities
  • Ear, Inner / abnormalities*
  • Female
  • Genes, Recessive
  • Male
  • Mice
  • Mice, Inbred ICR
  • Mice, Mutant Strains / anatomy & histology
  • Mice, Mutant Strains / genetics*
  • Mice, Mutant Strains / physiology
  • Pedigree
  • Phenotype