Relative potency of bombesin-like peptides

Br J Pharmacol. 1975 Oct;55(2):221-7. doi: 10.1111/j.1476-5381.1975.tb07631.x.


The pharmacological activity of two natural bombesin-like peptides, alytesin and litorin, and 25 related synthetic peptides has been compared to that of bombesin. 2 The minimum length of the amino acid chain required for the first appearance of bombesin-like effects was represented by the C-terminal heptapeptide, and the minimum length for maximal effects by the C-terminal nonapeptide. The latter possessed approximately the same activity as bombesin and may be considered a good substitute. 3 Both the tryptophan and histidine residues seemed to be essential for bombesin-like activity. 4 The C-terminal octapeptide was less active than either bombesin or the C-terminal nonapeptide and its action was more rapid in onset and less sustained. 5 Litorin apparently has an intermediate position between bombesin octapeptide and bombesin nonapeptide in the speed and duration of its effects. The relationship between structure and activity is discussed.

MeSH terms

  • Animals
  • Blood Pressure / drug effects
  • Bombesin / pharmacology*
  • Cats
  • Dogs
  • Female
  • Gallbladder / drug effects
  • Gastric Juice / metabolism
  • Gastric Mucosa / metabolism
  • Gastrins / metabolism
  • In Vitro Techniques
  • Intestines / drug effects
  • Muscle Contraction / drug effects
  • Muscle, Smooth / drug effects
  • Oligopeptides / pharmacology*
  • Peptides / pharmacology*
  • Rats
  • Structure-Activity Relationship
  • Time Factors
  • Urinary Bladder / drug effects
  • Uterine Contraction / drug effects


  • Gastrins
  • Oligopeptides
  • Peptides
  • alytesin
  • Bombesin