Role of adrenal stress hormones in forming lasting memories in the brain

Curr Opin Neurobiol. 2002 Apr;12(2):205-10. doi: 10.1016/s0959-4388(02)00306-9.


Recent experiments investigating the effects of adrenal stress hormones on memory provide extensive evidence that epinephrine and glucocorticoids modulate long-term memory consolidation in animals and human subjects. Release of norepinephrine and activation of beta-adrenoceptors within the basolateral amygdala is critical in mediating adrenal stress hormone regulation of memory consolidation.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adrenal Cortex Hormones / metabolism*
  • Adrenal Cortex Hormones / physiology
  • Amygdala / metabolism*
  • Amygdala / physiology
  • Animals
  • Brain / metabolism
  • Epinephrine / metabolism
  • Glucocorticoids / metabolism
  • Humans
  • Memory*
  • Receptors, Adrenergic / metabolism
  • Stress, Psychological / metabolism*


  • Adrenal Cortex Hormones
  • Glucocorticoids
  • Receptors, Adrenergic
  • Epinephrine