Fever: beneficial and detrimental effects of antipyretics

Curr Opin Infect Dis. 2002 Jun;15(3):241-5. doi: 10.1097/00001432-200206000-00005.


Although various forms of therapy have been used, since antiquity, to lower the temperature of febrile patients, it is still not known whether the benefits of antipyretic therapy outweigh its risks. Justifications for the use of antipyretic drugs, and the evidence pertaining to these rationales, are examined. Antipyretic therapy in sepsis, and adverse effects of antipyretic medications, are also reviewed.

Publication types

  • Review

MeSH terms

  • Analgesics, Non-Narcotic / adverse effects*
  • Analgesics, Non-Narcotic / therapeutic use*
  • Body Temperature Regulation
  • Brain Injuries / drug therapy
  • Clinical Trials as Topic
  • Cognition Disorders / drug therapy
  • Fever / drug therapy*
  • Fever / mortality
  • Fever / physiopathology
  • Humans
  • Seizures, Febrile / prevention & control
  • Sepsis / drug therapy
  • Stroke / drug therapy


  • Analgesics, Non-Narcotic