Circadian rhythms from flies to human

Nature. 2002 May 16;417(6886):329-35. doi: 10.1038/417329a.


In this era of jet travel, our body 'remembers' the previous time zone, such that when we travel, our sleep wake pattern, mental alertness, eating habits and many other physiological processes temporarily suffer the consequences of time displacement until we adjust to the new time zone. Although the existence of a circadian clock in humans had been postulated for decades, an understanding of the molecular mechanisms has required the full complement of research tools. To gain the initial insights into circadian mechanisms, researchers turned to genetically tractable model organisms such as Drosophila.

Publication types

  • Review

MeSH terms

  • Animals
  • Biological Clocks / genetics
  • Biological Clocks / physiology
  • Biological Evolution
  • Circadian Rhythm / genetics
  • Circadian Rhythm / physiology*
  • Drosophila / genetics
  • Drosophila / physiology*
  • Feedback, Physiological
  • Gene Expression Profiling
  • Gene Expression Regulation
  • Humans
  • Mutation
  • Sleep Wake Disorders / genetics
  • Sleep Wake Disorders / physiopathology