Rafting along the axon on Unc104 motors

Dev Cell. 2002 May;2(5):515-6. doi: 10.1016/s1534-5807(02)00177-6.

Abstract

Neurotransmission depends upon the fast axonal transport of synaptic vesicle precursors by the monomeric kinesin Unc104, a motor whose mechanism of action is a topic of debate. New work suggests that the formation of lipid raft domains triggers the assembly of vesicle-bound Unc104 dimers and the concomitant activation of processive movement, facilitating efficient long-range vesicle transport.

Publication types

  • Review

MeSH terms

  • Animals
  • Axonal Transport
  • Axons / physiology*
  • Caenorhabditis elegans Proteins / physiology
  • Kinesin / physiology
  • Membrane Microdomains / physiology
  • Molecular Motor Proteins / physiology*
  • Nerve Tissue Proteins / physiology*
  • Synaptic Transmission

Substances

  • Caenorhabditis elegans Proteins
  • Molecular Motor Proteins
  • Nerve Tissue Proteins
  • UNC-104 protein, C elegans
  • Kinesin