Cyclin G: a regulator of the p53-Mdm2 network

Dev Cell. 2002 May;2(5):518-9. doi: 10.1016/s1534-5807(02)00182-x.

Abstract

A recent study published in the April issue of Molecular Cell has shown that cyclin G, a p53 target, is a regulatory component of the active PP2A holoenzyme, which activates Mdm2 through dephosphorylation. These findings suggest that cyclin G is a key regulator of the p53-Mdm2 network.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis / physiology
  • Cyclin G
  • Cyclin G1
  • Cyclins / physiology*
  • Mice
  • Models, Biological
  • Nuclear Proteins*
  • Phosphoprotein Phosphatases / physiology
  • Proto-Oncogene Proteins / physiology*
  • Proto-Oncogene Proteins c-mdm2
  • Tumor Suppressor Protein p53 / physiology*

Substances

  • Ccng1 protein, mouse
  • Cyclin G
  • Cyclin G1
  • Cyclins
  • Nuclear Proteins
  • Proto-Oncogene Proteins
  • Tumor Suppressor Protein p53
  • Mdm2 protein, mouse
  • Proto-Oncogene Proteins c-mdm2
  • Phosphoprotein Phosphatases