RNA silencing: the genome's immune system

Science. 2002 May 17;296(5571):1263-5. doi: 10.1126/science.1072148.

Abstract

Genomes are databases sensitive to invasion by viruses. In recent years, a defense mechanism has been discovered, which turns out to be conserved among eukaryotes. The system can be compared to the immune system in several ways: It has specificity against foreign elements and the ability to amplify and raise a massive response against an invading nucleic acid. The latter property is beginning to be understood at the molecular level.

MeSH terms

  • Animals
  • Base Pairing
  • DNA Transposable Elements
  • Endoribonucleases / metabolism
  • Gene Silencing*
  • Humans
  • Immune System / physiology
  • Plants / genetics
  • RNA, Antisense / genetics
  • RNA, Antisense / metabolism
  • RNA, Double-Stranded / metabolism*
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • RNA, Plant / genetics
  • RNA, Plant / metabolism
  • RNA, Small Interfering
  • RNA, Untranslated / metabolism*
  • RNA-Dependent RNA Polymerase / metabolism
  • Ribonuclease III
  • Virus Physiological Phenomena
  • Viruses / genetics

Substances

  • DNA Transposable Elements
  • RNA, Antisense
  • RNA, Double-Stranded
  • RNA, Messenger
  • RNA, Plant
  • RNA, Small Interfering
  • RNA, Untranslated
  • RNA-Dependent RNA Polymerase
  • Endoribonucleases
  • Ribonuclease III