Decreased expression of Ku70/Ku80 proteins in malignant melanomas of the oral cavity

Anticancer Res. Jan-Feb 2002;22(1A):193-6.

Abstract

Ku70/80 are genes responsible for the repairing of DNA double-strand breaks and they function as a regulatory subunit of the DNA-dependent protein kinase. Their expression has not yet been investigated in malignant melanomas of the oral cavity. These tumours are characterized by very poor prognosis and etiology independent of UV-radiation. We investigated 29 malignant melanomas of the oral cavity for the expression of Ku70/80 proteins. Ku70 expression was preserved in 21 out of 29 tumours and the percentage of Ku70-positive cells did not exceed 76%. Ku80 was found in 19 out of 29 tumours and the percentage of Ku80-positive cells peaked at 62%. Correlations between Ku70 and Ku80 expression were lost (p>0.05). We conclude that decreased Ku70/80 expression in malignant melanomas of the oral cavity and loss of correlation between these markers may influence progression of oral melanomas.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antigens, Nuclear*
  • Biomarkers, Tumor / biosynthesis
  • Biomarkers, Tumor / genetics
  • DNA Helicases*
  • DNA Repair
  • DNA-Binding Proteins / biosynthesis*
  • DNA-Binding Proteins / genetics
  • Female
  • Gene Expression
  • Humans
  • Ku Autoantigen
  • Male
  • Melanoma / genetics
  • Melanoma / metabolism*
  • Middle Aged
  • Mouth Neoplasms / genetics
  • Mouth Neoplasms / metabolism*
  • Nuclear Proteins / biosynthesis*
  • Nuclear Proteins / genetics

Substances

  • Antigens, Nuclear
  • Biomarkers, Tumor
  • DNA-Binding Proteins
  • Nuclear Proteins
  • DNA Helicases
  • XRCC5 protein, human
  • Xrcc6 protein, human
  • Ku Autoantigen