Today, there is a worldwide infrastructure of offshore structure systems that include fixed, floating, and mobile platforms, pipelines, and ships. Background on current and future trends in development of comprehensive programs to help improve the quality and reliability of offshore structure systems are discussed. A combination of proactive, reactive, and interactive risk assessment and management approaches have been developed and applied. Two risk assessment and management instruments are detailed in this article: a qualitative Quality Management Assessment System (QMAS), and a quantitative System Risk Analysis System (SYRAS). Application of QMAS to produce human and organizational performance shaping factors that are used as input to SYRAS is discussed.