Persistent polyclonal B-cell lymphocytosis

Acta Clin Belg. 2002 Jan-Feb;57(1):31-3. doi: 10.1179/acb.2002.008.


We present a case of persistent polyclonal B-cell lymphocytosis (PPBL). This syndrome is characterized by a persistent lymphocytosis with circulating atypical binucleated lymphocytes. The patient had serological evidence of a previous EBV infection, had raised polyclonal serum IgM levels and was a heavy smoker. No malignancy was detected.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • B-Lymphocytes / immunology*
  • Epstein-Barr Virus Infections
  • Female
  • Humans
  • Immunoglobulin M / analysis
  • Lymphocytosis / etiology
  • Lymphocytosis / immunology*
  • Lymphocytosis / pathology
  • Smoking


  • Immunoglobulin M