A cohort study of dietary carotenoids and lung cancer risk in women (Canada)

Cancer Causes Control. 2002 Apr;13(3):231-7. doi: 10.1023/a:1015048619413.


Objective: To investigate the association between dietary carotenoid intake and lung cancer risk in women.

Methods: A case-cohort study was undertaken in the Canadian National Breast Screening Study dietary cohort, which consists of 56,837 women who completed a self-administered dietary questionnaire. The cohort was recruited between 1980 and 1985, and during follow-up to the end of 1993 a total of 196 cohort members were diagnosed with incident lung cancer. For analysis, a subcohort consisting of a random sample of 5681 women was selected from the full dietary cohort. After exclusions for various reasons, the analyses were based on 155 cases and 5,361 non-cases.

Results: When compared to those in the lowest quartile level of intake, the adjusted incidence rate ratios (95% confidence intervals) for those in the highest quartile levels of alpha-carotene, beta-carotene, beta-cryptoxanthin, lycopene, and lutein intake were 0.90 (0.51-1.58). 1.40 (0.76-2.59), 0.66 (0.33-1.32), 1.04 (0.61-1.76), and 1.26 (0.70-2.24), respectively; none of the associated tests for trend was statistically significant.

Conclusion: These results suggest that there is no association between dietary carotenoid intake and lung cancer risk. at least for the range of intakes observed here.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Distribution
  • Canada / epidemiology
  • Carotenoids / administration & dosage*
  • Case-Control Studies
  • Cohort Studies
  • Confidence Intervals
  • Diet*
  • Dietary Supplements*
  • Female
  • Humans
  • Lung Neoplasms / epidemiology*
  • Lung Neoplasms / prevention & control*
  • Middle Aged
  • Poisson Distribution
  • Prevalence
  • Probability
  • Reference Values
  • Risk Assessment
  • Risk Factors
  • Surveys and Questionnaires
  • Survival Analysis


  • Carotenoids