Prevalence of ICA-12 and other autoantibodies in north Indian patients with early-onset diabetes

Ann N Y Acad Sci. 2002 Apr:958:214-7. doi: 10.1111/j.1749-6632.2002.tb02972.x.

Abstract

This study attempts to assess the prevalence of various autoantibodies in early-onset diabetics in northern India, with emphasis on antibodies against glutamic acid decarboxylase (GAD65), IA-2, ICA-12, 21-hydroxylase (21-OH), and tissue transglutaminase (TTG). GAD65 and IA-2 antibodies were found to be present in approximately 26% of cases of type 1 diabetes. A subset of patients clinically diagnosed to have MMDM appears to have an autoimmune etiology, with more than 20% showing serpositivity for IA-2 antibodies. Antibodies against ICA-12 were prevalent in both type 1 diabetes and MMDM. Approximately one of seven patients with type 1 diabetes showed erological evidence of celiac disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age of Onset
  • Autoantibodies / blood
  • Autoantibodies / immunology*
  • Autoantigens / blood
  • Autoantigens / immunology*
  • Cohort Studies
  • Diabetes Mellitus, Type 1 / blood
  • Diabetes Mellitus, Type 1 / epidemiology
  • Diabetes Mellitus, Type 1 / immunology*
  • Female
  • High Mobility Group Proteins / blood
  • High Mobility Group Proteins / immunology*
  • Humans
  • India / epidemiology
  • Male
  • SOXD Transcription Factors

Substances

  • Autoantibodies
  • Autoantigens
  • High Mobility Group Proteins
  • SOX13 protein, human
  • SOXD Transcription Factors