Iodopropynyl butylcarbamate

Am J Contact Dermat. 2002 Jun;13(2):77-9.


Iodopropynyl butylcarbamate (IPBC) is an internationally recognized chemical that has been used for years because of its wide field of application. Initially used as a water-based paint and wood preservative and then in metalworking fluids, its role has expanded into the more recent uses in cosmetic products. The need for a potent, broad-spectrum, and safe preservative system in cosmetics allowed for the discovery of several combinations of IPBC effective against a wide variety of organisms. Although IPBC has claimed to be safe when used at concentrations less than 0.1%, the introduction of IPBC into cosmetics has led to several reports labeling IPBC as a potential new contact allergen. As the use of this seemingly safe preservative becomes vast, an increased number of cases of IPBC-induced contact allergy is likely.

Publication types

  • Review

MeSH terms

  • Allergens / adverse effects*
  • Carbamates / adverse effects*
  • Cosmetics / adverse effects*
  • Dermatitis, Allergic Contact / etiology*
  • Humans
  • Patch Tests / standards
  • Preservatives, Pharmaceutical / adverse effects*


  • Allergens
  • Carbamates
  • Cosmetics
  • Preservatives, Pharmaceutical
  • 3-iodo-2-propynylbutylcarbamate