Signalling in viral entry

Cell Mol Life Sci. 2002 Apr;59(4):608-26. doi: 10.1007/s00018-002-8453-3.


Viral infections are serious battles between pathogens and hosts. They can result in cell death, elimination of the virus or latent infection keeping both cells and pathogens alive. The outcome of an infection is often determined by cell signalling. Viruses deliver genomes and proteins with signalling potential into target cells and thereby alter the metabolism of the host. Virus interactions with cell surface receptors can elicit two types of signals, conformational changes of viral particles, and intracellular signals triggering specific cellular reactions. Responses by cells include stimulation of innate and adaptive immunity, growth, proliferation, survival and apoptosis. In addition, virus-activated cell signalling boosts viral entry and gene delivery, as recently shon for adenoviruses and adeno-associated viruses. This review illustrates that multiple activation of host cells during viral entry profoundly impacts the elaborate relationship between hosts and viral pathogens.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenoviridae / metabolism
  • Adenoviridae / pathogenicity
  • Animals
  • Cell Survival
  • Endocytosis
  • Humans
  • MAP Kinase Signaling System
  • Mice
  • Parvovirus / metabolism
  • Parvovirus / pathogenicity
  • Proto-Oncogene Proteins p21(ras) / metabolism
  • Receptors, Virus / metabolism
  • Signal Transduction*
  • Virion / metabolism
  • Virion / ultrastructure
  • Virus Diseases / immunology
  • Virus Diseases / metabolism
  • Virus Diseases / virology
  • Viruses / pathogenicity*


  • Receptors, Virus
  • HRAS protein, human
  • Proto-Oncogene Proteins p21(ras)