And all of a sudden it's over: mitochondrial outer-membrane permeabilization in apoptosis

Biochimie. Feb-Mar 2002;84(2-3):113-21. doi: 10.1016/s0300-9084(02)01379-2.


Identification of pro-apoptotic activities for a variety of proteins normally resident in the mitochondrial inter-membrane space has substantiated the role of mitochondria as integral to the apoptotic process. Cytochrome c is involved in apoptosome formation and caspase activation, SMAC/Diablo deregulates the inhibitor of apoptosis proteins, apoptosis-inducing factor may play a role in chromatin condensation and release of other proteins such as adenylate kinase may adversely affect cellular metabolism and contribute to the death of a cell if the downstream apoptotic pathway is blocked. It is still unclear how these proteins are released from the mitochondria. Recent advances in our knowledge of mitochondrial outer-membrane permeabilization and the consequences of this event on mitochondria will be discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Apoptosis / physiology*
  • Cell Membrane / physiology*
  • Cell Membrane Permeability / physiology*
  • Cytochrome c Group / metabolism
  • Energy Metabolism
  • Humans
  • Ion Channels / physiology
  • Mitochondria / physiology*
  • Mitochondrial Membrane Transport Proteins
  • Mitochondrial Permeability Transition Pore


  • Cytochrome c Group
  • Ion Channels
  • Mitochondrial Membrane Transport Proteins
  • Mitochondrial Permeability Transition Pore
  • Adenosine Triphosphate