Experimental ulcerative disease of the colon

Methods Achiev Exp Pathol. 1975;7:56-71.


The oral administration to guinea-pigs of an aqueous solution of carrageenan derived from the red seaweed, Eucheuma spinosum, provides a useful, readily available experimental model for the study of ulcerative disease of the colon. Two types of ulcerative disease can be produced within a 4-6 week period, viz., ulceration localised mainly to the caecum by using 1% undegraded carrageenan in the drinking fluid, and extensive ulceration involving caecum, colon, and rectum by using 5% degraded carrageenan. Ulceration is probably due to the local action of carrageenan in the bowel.

MeSH terms

  • Animals
  • Carrageenan
  • Colitis* / pathology
  • Colitis, Ulcerative / chemically induced
  • Colon / pathology
  • Crohn Disease / chemically induced
  • Disease Models, Animal*
  • Guinea Pigs*
  • Humans
  • Male


  • Carrageenan