Cutting edge: immune cells as sources and targets of the IL-10 family members?

J Immunol. 2002 Jun 1;168(11):5397-402. doi: 10.4049/jimmunol.168.11.5397.

Abstract

This study investigated the expression of five novel human IL-10-related molecules and their receptors in blood mononuclear cells. IL-19 and IL-20 were found to be preferentially expressed in monocytes. IL-22 and IL-26 (AK155) expression was exclusively detected in T cells, especially upon type 1 polarization, and in NK cells. IL-24 (melanoma differentiation-associated gene 7) expression was restricted to monocytes and T cells. Detection of these molecules in lymphocytes was predominantly linked to cellular activation. Regarding T cells, IL-26 was primarily produced by memory cells, and its expression was independent on costimulation. In contrast to the high expression of receptors for IL-10 homologs in different tissues and cell lines, monocytes and NK, B, and T cells showed clear expression only of IL-10R1, IL-10R2, and IL-20R2. In these cells, IL-20R2 might be part of a still-unknown receptor complex. Therefore, immune cells may represent a major source but a minor target of the novel IL-10 family members.

MeSH terms

  • Genes, Tumor Suppressor
  • Growth Substances / genetics*
  • Humans
  • Interleukin-10 / genetics*
  • Interleukin-22
  • Interleukins / genetics*
  • Leukocytes, Mononuclear / metabolism*
  • RNA, Messenger / analysis
  • Receptors, Interleukin / genetics
  • Receptors, Interleukin-10

Substances

  • Growth Substances
  • IL19 protein, human
  • IL26 protein, human
  • Interleukins
  • RNA, Messenger
  • Receptors, Interleukin
  • Receptors, Interleukin-10
  • interleukin-24
  • Interleukin-10
  • interleukin 20