Regulation of membrane type-matrix metalloproteinases

Semin Cancer Biol. 2002 Apr;12(2):131-8. doi: 10.1006/scbi.2001.0421.


Pericellular proteolysis is a hallmark of tumor cell metastasis. The membrane type (MT)-matrix metalloproteinases (MMPs) constitute a distinctive group of membrane-bound MMPs that are central mediators of surface proteolytic events that regulate tumor cell motility, metastasis and angiogenesis. As membrane-tethered proteases, the MT-MMPs exhibit unique regulatory mechanisms and interactions with metalloproteinase inhibitors and other relevant molecules. This review will focus on new emerging information on the mechanisms that regulate MT-MMP processing, activity and inhibition, and their significance for enzyme function in the tumor microenvironment.

Publication types

  • Review

MeSH terms

  • Cell Membrane / enzymology
  • Enzyme Activation
  • Enzyme Precursors / metabolism
  • Humans
  • Matrix Metalloproteinases, Membrane-Associated
  • Metalloendopeptidases / antagonists & inhibitors
  • Metalloendopeptidases / chemistry
  • Metalloendopeptidases / metabolism*
  • Neoplasms / enzymology*


  • Enzyme Precursors
  • Matrix Metalloproteinases, Membrane-Associated
  • Metalloendopeptidases