An interdisciplinary forum to examine systems related to clinical practice strengthens collaboration and capitalizes on the collective knowledge base of all members. The success of the clinical practice committee is dependent primarily on the ability of the group to negotiate complex systems, as well as authorize changes in clinical practice. The nurse leader plays a critical role as facilitator and mentor in this process. This report describes the evolution of the clinical practice committees at Children's Hospital Boston, provides practical strategies for group development, includes methods to maximize the effectiveness of a diverse group, and presents examples of system improvements and outcomes that have emerged from this interdisciplinary team.