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Clinical Trial
. 2002 Jun;16(6):1101-7.
doi: 10.1046/j.1365-2036.2002.01268.x.

Effects of Anti-Tumour Necrosis Factor-Alpha Therapy on the Quality of Life in Crohn's Disease

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Clinical Trial

Effects of Anti-Tumour Necrosis Factor-Alpha Therapy on the Quality of Life in Crohn's Disease

B P J van Balkom et al. Aliment Pharmacol Ther. .
Free article

Abstract

Background: Infusion of anti-tumour necrosis factor-alpha appears to be highly effective in patients with Crohn's disease.

Aim: To assess the effect of infliximab on the quality of life in patients with active or fistulizing disease, as measured by the inflammatory bowel disease questionnaire, and to examine the impact on its four dimensions.

Methods: An observational study was conducted in 65 patients. An infusion of 5 mg/kg infliximab was given at week 0 in patients with active disease and at week 0, 2 and 6 in fistulizing disease. Changes from baseline in the total and dimensional inflammatory bowel disease questionnaire scores were calculated and compared between the patient groups. Potential predictors of change in the quality of life were identified.

Results: In the active disease group, at week 4, the mean total and dimensional inflammatory bowel disease questionnaire scores improved compared to baseline (P < 0.001). In the fistulizing group, at week 6, all scores changed from baseline (P < 0.05). Improvement in the total inflammatory bowel disease questionnaire score correlated well with the improvement of the Crohn's disease activity index. Systemic and social scores improved more than bowel and emotional scores. Inflammatory Crohn's disease and a young age at diagnosis were predictors for a better response to infliximab therapy.

Conclusions: Infliximab therapy improves all dimensions of the quality of life in patients with Crohn's disease.

Comment in

  • Infliximab and Crohn's QOL.
    Wicks AC, Thomas C, Curran R, Mayberry JF. Wicks AC, et al. Aliment Pharmacol Ther. 2002 Oct;16(10):1831-2. doi: 10.1046/j.1365-2036.2002.t01-1-01329_2.x. Aliment Pharmacol Ther. 2002. PMID: 12269979 No abstract available.

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