Ceftriaxone-induced haemolytic anaemia in a child with no immune deficiency or haematological disease

J Paediatr Child Health. 2002 Apr;38(2):209-10. doi: 10.1046/j.1440-1754.2002.00778.x.

Abstract

A 5-year-old girl, with no underlying immune deficiency or haematologic disease, was treated with ceftriaxone for a urinary tract infection. After receiving ceftriaxone intramuscularly, massive haemolytic anaemia developed. Laboratory studies showed the presence of an antibody against ceftriaxone, and the findings reflected immune complex type haemolysis. High-dose corticosteroids appeared to be effective therapeutically.

Publication types

  • Case Reports

MeSH terms

  • Amikacin / administration & dosage
  • Anemia, Hemolytic / chemically induced*
  • Anemia, Hemolytic / drug therapy
  • Antigen-Antibody Complex
  • Ceftriaxone / adverse effects*
  • Cephalosporins / adverse effects*
  • Child, Preschool
  • Drug Therapy, Combination / administration & dosage
  • Female
  • Humans
  • Methylprednisolone / therapeutic use
  • United States
  • Urinary Tract Infections / drug therapy

Substances

  • Antigen-Antibody Complex
  • Cephalosporins
  • Ceftriaxone
  • Amikacin
  • Methylprednisolone