Abstract
A 5-year-old girl, with no underlying immune deficiency or haematologic disease, was treated with ceftriaxone for a urinary tract infection. After receiving ceftriaxone intramuscularly, massive haemolytic anaemia developed. Laboratory studies showed the presence of an antibody against ceftriaxone, and the findings reflected immune complex type haemolysis. High-dose corticosteroids appeared to be effective therapeutically.
MeSH terms
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Amikacin / administration & dosage
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Anemia, Hemolytic / chemically induced*
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Anemia, Hemolytic / drug therapy
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Antigen-Antibody Complex
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Ceftriaxone / adverse effects*
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Cephalosporins / adverse effects*
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Child, Preschool
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Drug Therapy, Combination / administration & dosage
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Female
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Humans
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Methylprednisolone / therapeutic use
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United States
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Urinary Tract Infections / drug therapy
Substances
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Antigen-Antibody Complex
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Cephalosporins
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Ceftriaxone
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Amikacin
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Methylprednisolone