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. 2002 Jun 3;12(11):1507-10.
doi: 10.1016/s0960-894x(02)00185-3.

Electrochemical and Peroxidase Oxidation Study of N'-hydroxyguanidine Derivatives as NO Donors

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Electrochemical and Peroxidase Oxidation Study of N'-hydroxyguanidine Derivatives as NO Donors

Tingwei Cai et al. Bioorg Med Chem Lett. .

Abstract

The electrochemical properties of a series of N-substituted-N'-hydroxyguanidines were studied. Two oxidation potentials of each compound were obtained by cyclic voltammetry. The E(ox1) values were from 0.51 to 0.62V, while the E(ox2) values were from 1.14 to 1.81V in acetonitrile solution. Next, their enzymatic controlled NO release abilities were evaluated. All N'-hydroxyguanidines exhibited efficient NO release abilities under the oxidation by horseradish peroxidase in the presence of H(2)O(2).

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