The acute and short-time effect of supplementation with the combination of n-3 fatty acids and acetylsalicylic acid on platelet function and plasma lipids

Thromb Res. 2002 Feb 15;105(4):311-6. doi: 10.1016/s0049-3848(02)00010-5.


Antiplatelet therapy with acetylsalicylic acid (ASA) is commonly used to reduce the risk of cardio- and cerebrovascular events. Fish consumption has been inversely related to coronary disease, which has been partly attributed to an inhibitory effect of n-3 polyunsaturated fatty acids (n-3 PUFA) on platelet production of tromboxane A2. In this study, we investigated the acute and short-time effect of supplementation with n-3 PUFA and intravenous ASA on platelet function, platelet fatty acid composition and plasma lipids. Eighteen healthy men were randomly allocated to a daily intake of 10 g n-3 PUFA or placebo. After this supplement (14 h and 14 days), blood was sampled before and after intravenous injection of 100 mg ASA. n-3 PUFA given for 14 days caused a minor inhibition of platelet reactivity but negligible compared to 100 mg ASA. No additive effect of n-3 PUFA and ASA could be demonstrated.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Adult
  • Aspirin / administration & dosage*
  • Blood Platelets / drug effects*
  • Blood Platelets / physiology*
  • Double-Blind Method
  • Drug Interactions
  • Fatty Acids / blood
  • Fatty Acids, Omega-3 / administration & dosage*
  • Humans
  • Injections, Intravenous
  • Lipids / blood*
  • Lipoproteins / blood
  • Male
  • Middle Aged
  • Platelet Aggregation Inhibitors / administration & dosage
  • Time Factors


  • Fatty Acids
  • Fatty Acids, Omega-3
  • Lipids
  • Lipoproteins
  • Platelet Aggregation Inhibitors
  • Aspirin