Markers of chronic inflammation and obesity: a prospective study on the reversibility of this association in middle-aged women undergoing weight loss by surgical intervention

Int J Obes Relat Metab Disord. 2002 May;26(5):659-62. doi: 10.1038/sj.ijo.0801970.


Background: Human adipose tissue expresses and releases proinflammatory cytokines and these measures of chronic inflammation have recently been associated with obesity.

Hypothesis: To test whether the proinflammatory state is reversible in subjects undergoing weight loss by surgical measures.

Subjects and methods: Twenty morbidly obese women participated in this prospective study. Subjects were examined for fat mass, high-sensitive C-reactive protein (hs-CRP), interleukin 6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) before and 1 y after Swedish adjustable gastric banding.

Results: Anthropometric measures displayed a significant reduction of the body mass index (BMI) from 41.6+/-5.4 to 30.8+/-6.1 kg/m(2) and the fat mass from 53.9+/-10.3 to 29.8+/-12.1 kg (mean+/-s.d.). Hs-CRP levels decreased significantly from 1.33+/-1.21 mg/dl in pre-gastric banding subjects to 0.40+/-0.61 mg/dl in post-gastric banding subjects, respectively. IL-6 and TNF-alpha levels did not differ significantly between pre- and post-gastric banding subjects.

Conclusions: We speculate that in these patients the marked reduction in C-reactive protein might be beneficial in reducing their cardiovascular risk and is not solely mediated by IL-6 and TNF-alpha.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipose Tissue
  • Adult
  • Biomarkers / blood*
  • Body Composition
  • C-Reactive Protein / analysis
  • Cholesterol / blood
  • Female
  • Gastroplasty
  • Humans
  • Inflammation / blood*
  • Insulin / blood
  • Interleukin-6 / blood
  • Leptin / blood
  • Middle Aged
  • Obesity / blood*
  • Obesity / surgery*
  • Prospective Studies
  • Triglycerides / blood
  • Tumor Necrosis Factor-alpha / analysis
  • Weight Loss*


  • Biomarkers
  • Insulin
  • Interleukin-6
  • Leptin
  • Triglycerides
  • Tumor Necrosis Factor-alpha
  • C-Reactive Protein
  • Cholesterol