The analysis of binary responses from toxicological experiments involving reproduction and teratogenicity

Biometrics. 1975 Dec;31(4):949-52.


This paper describes a parametric method for analyzing binary response data from completely randomized experiments in which the experimental units are animal litters. Responses within a litter are assumed to form a set of Bernoulli trials whose success probability varies between litters in the same treatment group according to a two parameter beta distribution. The parameters of the beta distribution for each treatment are estimated by maximum likelihood and treatment differences are tested by asymptotic likelihood ratio tests.

MeSH terms

  • Animals
  • Female
  • Pregnancy
  • Statistics as Topic*
  • Teratogens*
  • Toxicology*


  • Teratogens