The Nck family of adapter proteins: regulators of actin cytoskeleton

Cell Signal. 2002 Sep;14(9):723-31. doi: 10.1016/s0898-6568(02)00027-x.


SH2/SH3 domain-containing adapter proteins, such as the Nck family, play a major role in regulating tyrosine kinase signalling. They serve to recruit proline-rich effector molecules to tyrosine-phosphorylated kinases or their substrates. Initially, it was not clear why cells from nematodes to vertebrates contain redundant and closely related SH2/SH3 adapters, such as Grb2, Crk and Nck. Recent evidence suggests that their biological roles are clearly different, whereas, for example, Grb2 connects activated receptor tyrosine kinases to Sos and Ras, leading to cell proliferation. The proteins of Nck family are implicated in organisation of actin cytoskeleton, cell movement or axon guidance in flies. In this review, the author attempts to summarise signalling pathways in which Nck plays a critical role.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Actin Cytoskeleton / metabolism*
  • Adaptor Proteins, Signal Transducing
  • Animals
  • Axons / physiology
  • Drosophila Proteins
  • Integrins / metabolism
  • Lymphocyte Activation
  • Models, Biological
  • Nerve Tissue Proteins / physiology
  • Oncogene Proteins / chemistry
  • Oncogene Proteins / physiology*
  • Protein-Serine-Threonine Kinases / metabolism
  • Proto-Oncogene Proteins p21(ras) / metabolism
  • Signal Transduction*
  • T-Lymphocytes / immunology
  • src Homology Domains


  • Adaptor Proteins, Signal Transducing
  • Drosophila Proteins
  • Integrins
  • Nck protein
  • Nerve Tissue Proteins
  • Oncogene Proteins
  • dock protein, Drosophila
  • Protein-Serine-Threonine Kinases
  • Proto-Oncogene Proteins p21(ras)