Temporal subtraction for detection of solitary pulmonary nodules on chest radiographs: evaluation of a commercially available computer-aided diagnosis system

Radiology. 2002 Jun;223(3):806-11. doi: 10.1148/radiol.2233010957.


Purpose: To evaluate the usefulness of a commercially available computer-aided diagnosis (CAD) system that incorporates temporal subtraction for the detection of solitary pulmonary nodules on chest radiographs by readers with different levels of experience.

Materials and methods: Sixty pairs of chest radiographs in 30 patients with newly detected solitary pulmonary nodules and 30 normal cases, all confirmed with serial chest computed tomography (CT), were obtained from screen-film or digital radiographic systems and were digitized (spatial resolution, 0.171 mm/pixel). Temporal subtraction images were produced with an iterative image-warping technique. Five chest radiologists and five residents evaluated both image sets for solitary nodules: set A, current and prior radiographs with temporal subtraction images, and set B, current and prior radiographs only. Assessment was performed with receiver operating characteristic (ROC) analysis of the images on a monitor (pixel size, 1,280 x 1,024) equipped with the system. The reading time needed by each reader was recorded in each case.

Results: For the chest radiologists, no statistically significant difference was found between set A (area under the ROC curve [A(z)] = 0.934) and set B (A(z) = 0.964). For the residents, however, observer performance in set A (A(z) = 0.907) was superior to that in set B (A(z) = 0.855) (P <.05). For both groups, the mean reading time per case for set A (chest radiologists, 16.7 seconds; residents, 15.7 seconds) was significantly (P <.05) shorter than that for set B (chest radiologists, 20.4 seconds; residents, 26.2 seconds).

Conclusion: For the detection of solitary pulmonary nodules, the CAD system with temporal subtraction can promote efficiency for established chest radiologists and improvement in accuracy for less experienced readers.

Publication types

  • Evaluation Study

MeSH terms

  • Adult
  • Aged
  • Case-Control Studies
  • Diagnosis, Computer-Assisted*
  • Female
  • Humans
  • Lung Neoplasms / diagnostic imaging*
  • Lung Neoplasms / pathology
  • Male
  • Middle Aged
  • ROC Curve
  • Radiographic Image Enhancement / methods
  • Radiography, Thoracic
  • Sensitivity and Specificity
  • Subtraction Technique