Effect of amine fluoride toothpaste and gel in high risk groups of Hungarian adolescents: results of a longitudinal study

Caries Res. 2002 Mar-Apr;36(2):142-6. doi: 10.1159/000057873.


The aim of the study was to establish a preventive program with the combined use of amine fluoride toothpaste and gel in groups of adolescents living in different locations in Hungary. Caries and oral hygiene examinations were performed at the beginning of the study and repeated after 1 and 2 years. The adolescents were divided into 3 groups: 1 control and 2 test groups. The control group continued its usual oral care habits. One of the test groups received Elmex toothpaste for unsupervised home use daily and Elmex gel for use once a week, and the other test group received Elmex toothpaste and only placebo gel. The combined use of amine fluoride-containing toothpaste and gel provided a significant reduction in DMFS mean values (38% including white spot lesions, 34% not including white spot lesions, p < 0.05) and in visible plaque index values (18%, p < 0.05) compared to the control group.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Amines / administration & dosage*
  • DMF Index
  • Dental Caries / prevention & control*
  • Diamines
  • Fluorides / administration & dosage*
  • Fluorides, Topical / therapeutic use*
  • Gels / therapeutic use
  • Humans
  • Hungary
  • Longitudinal Studies
  • Toothpastes / therapeutic use*


  • Amines
  • Diamines
  • Fluorides, Topical
  • Gels
  • Toothpastes
  • Olaflur
  • Fluorides