Autoantibodies to amphiphysin I and amphiphysin II in a patient with sensory-motor neuropathy

Eur Neurol. 2002;47(4):196-200. doi: 10.1159/000057898.


A proportion of patients with peripheral neuropathies has circulating autoantibodies directed against neural antigens. In some cases, autoantibodies may play a pathogenic role. We studied a patient with a progressive sensory-motor axonal neuropathy of unknown etiology, looking for circulating autoantibodies against neural antigens and we showed that the patient's serum contained anti-amphiphysin I (AMP I) and amphiphysin II (AMP II) autoantibodies. A sural nerve biopsy revealed an axonal neuropathy. Indirect immunofluorescence experiments with the patient's serum showed a staining of rat axons due to alpha-AMP I autoantibodies and a specific labelling of cytoplasm and Schmidt-Lanterman incisures of Schwann cells due to alpha-AMP II autoantibodies. In conclusion we identified a patient affected by a sensory-motor neuropathy with autoantibodies against both AMP I and AMP II.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Autoantibodies / immunology*
  • Blotting, Western
  • Fluorescent Antibody Technique
  • Hereditary Sensory and Autonomic Neuropathies / immunology*
  • Hereditary Sensory and Autonomic Neuropathies / physiopathology
  • Humans
  • Male
  • Motor Neurons / pathology
  • Nerve Tissue Proteins / immunology*
  • Neural Conduction / physiology


  • Autoantibodies
  • Nerve Tissue Proteins
  • amphiphysin