The effect of (-)-hydroxycitrate on energy intake and satiety in overweight humans

Int J Obes Relat Metab Disord. 2002 Jun;26(6):870-2. doi: 10.1038/sj.ijo.0801979.


Objective: Assessment of the effects of 2 weeks of daily administration of HCA on energy intake and satiety in overweight men and women.

Design: A 6-week randomized placebo-controlled single-blinded cross-over trial.

Subjects: consumed three times daily for 2 weeks 100 ml tomato juice (placebo) and, separated by a 2 week wash-out period, 100 ml tomato juice with 300 mg HCA.Subjects: Twelve males and 12 females (body mass index 27.5+/-2.0 kg/m(2); age 37+/-10 y).

Measurements: After 2 weeks, 24 h energy intake (EI), appetite profile, hedonics, mood and possible change in dietary restraint were assessed in the laboratory restaurant. Prevention of degradation and bio-availability was documented.

Results: Twenty-four-hour EI was decreased by 15-30% (P<0.05) with HCA treatment compared to placebo, without changes in the appetite profile, dietary restraint, mood, taste perception and hedonics, while body weight tended to decrease (P=0.1).

Conclusion: HCA treatment reduced 24 h EI in humans while satiety was sustained.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Affect / drug effects
  • Appetite / drug effects
  • Citrates / administration & dosage*
  • Citrates / therapeutic use
  • Energy Intake / drug effects*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Placebos
  • Satiation / drug effects*
  • Taste / drug effects


  • Citrates
  • Placebos
  • hydroxycitric acid