SET-domain proteins of the Su(var)3-9, E(z) and trithorax families

Gene. 2002 Feb 20;285(1-2):25-37. doi: 10.1016/s0378-1119(02)00401-8.


SET-domain (SET: Su(var)3-9, E(z) and Trithorax)-containing proteins were collected through sequence searches of the available databases. After removing redundancies, the proteins belonging to three families, SU(VAR)3-9, E(Z) and Trithorax, were selected. Analysis of the relationship between the different members is based on pairwise alignment, compilation, and comparison of their SET-domains. The level of homology of the SET-domains defined the distribution of the proteins into families and into clades within the families. The architecture of the entire protein supported the distribution pattern built upon SET-domain similarity. Parallel cladistic and protein-architecture analyses outlined two plausible criteria for predicting function.

Publication types

  • Review

MeSH terms

  • Animals
  • DNA-Binding Proteins / genetics*
  • Drosophila Proteins*
  • Evolution, Molecular*
  • Gene Expression Regulation
  • Humans
  • Nuclear Proteins / genetics*
  • Phylogeny
  • Plants / genetics
  • Polycomb Repressive Complex 2
  • Repressor Proteins / genetics*
  • Transcription Factors*


  • DNA-Binding Proteins
  • Drosophila Proteins
  • Nuclear Proteins
  • Repressor Proteins
  • Su(var)3-9 protein, Drosophila
  • Transcription Factors
  • Trl protein, Drosophila
  • E(z) protein, Drosophila
  • Polycomb Repressive Complex 2