Is meconium passage a risk factor for maternal infection in term pregnancies?

Obstet Gynecol. 2002 Apr;99(4):548-52. doi: 10.1016/s0029-7844(01)01786-0.

Abstract

Objective: To study the association between meconium and maternal infection.

Methods: This was a retrospective cohort study of 678 pregnant women. All term deliveries during a 31-month period with meconium passage were included. Each meconium delivery was matched with a consecutive delivery without meconium at the same gestational age.

Results: The overall infection rate was 16%, with 13% of the infections directly related to the pregnancy, labor, and delivery. The endometritis rate was 5%, with 7.1% and 3% in the meconium and no-meconium group, respectively. The chorioamnionitis rate was 8.3%, with 9.5% in the meconium and 7.1% in the no-meconium group. Factors found to be associated with overall obstetric infections had the following odds ratios (ORs) and 95% confidence intervals (CIs): meconium (OR 1.8, 95% CI 1.1, 2.8), internal monitoring (OR 3.4, 95% CI 1.9, 5.9), amnioinfusion (OR 2.0, 95% CI 1.3, 3.3), number of vaginal exams (OR 4.5, 95% CI 2.8, 7.1), length of labor (OR 2.8, 95% CI 1.8, 4.4), and cesarean (OR 3.1, 95% CI 1.9, 5.1). Logistic regression analyses revealed the following ORs and 95% CIs: 1) for endometritis-cesarean (OR 4.2, 95% CI 1.9, 8.9), internal monitoring (OR 2.5, 95% CI 1.1, 5.9), and meconium (OR 2.5, 95% CI 1.1, 5.5), and 2) for chorioamnionitis-length of labor greater than 10 hours (OR 2.7, 95% CI 1.4, 5.6), number of vaginal exams greater than seven (OR 3.4, 95% CI 1.7, 6.6), and use of internal monitors (OR 2.5, 95% CI 1.2, 5.3).

Conclusion: Meconium passage increases the risk of postpartum endometritis but not chorioamnionitis. Length of labor, internal monitoring, and number of vaginal exams are risk factors for chorioamnionitis.

MeSH terms

  • Adult
  • Case-Control Studies
  • Chorioamnionitis / epidemiology*
  • Cohort Studies
  • Endometritis / epidemiology*
  • Female
  • Gestational Age
  • Humans
  • Labor, Obstetric
  • Logistic Models
  • Mastitis / epidemiology
  • Meconium*
  • Obstetric Labor Complications / epidemiology*
  • Otitis Media / epidemiology
  • Pregnancy
  • Respiratory Tract Infections / epidemiology
  • Retrospective Studies
  • Risk Factors
  • Urinary Tract Infections / epidemiology