Abstract
The title compound, useful for testing the efficacy of heparin sulfamidase, was synthesized in good yield starting from 2-azido-2-deoxy-3,4,6-tri-O-acetyl-D-glucopyranosyl fluoride, reducing the azido group efficiently with SnCl(2)-PhSH-Et(3)N reagent and finally crystallizing the N-sulfated product from methanol after deacetylation.
MeSH terms
-
Coumarins / chemical synthesis*
-
Fluorescent Dyes
-
Hydrolases / metabolism*
-
Monosaccharides / chemical synthesis*
-
Mucopolysaccharidosis III / metabolism
-
Substrate Specificity
Substances
-
7-O-(2-deoxy-2-sulfamido-alpha-D-glucopyranosyl)-4-methylcoumarin sodium salt
-
Coumarins
-
Fluorescent Dyes
-
Monosaccharides
-
Hydrolases
-
N-sulfoglucosamine sulfohydrolase