Abstract
The SAR studies to optimise both potency and rate of clearance in the rat for a series of pyrimidine and pyridine based VLA-4 antagonists are described.
MeSH terms
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Integrin alpha4beta1 / antagonists & inhibitors*
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Phenylalanine / analogs & derivatives
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Phenylalanine / chemistry*
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Phenylalanine / pharmacology*
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Pyridines / chemistry*
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Pyridines / pharmacology*
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Pyrimidines / chemistry*
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Pyrimidines / pharmacology*
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Structure-Activity Relationship
Substances
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Integrin alpha4beta1
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N-(pyridin-2-yl) phenylalanine
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N-(pyrimidin-4-yl) phenylalanine
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Pyridines
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Pyrimidines
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Phenylalanine