Vitamin D(3): synthesis of seco-C-9,11-bisnor-17-methyl-1 alpha,25-dihydroxyvitamin D(3) analogues

Bioorg Med Chem Lett. 2002 Jun 17;12(12):1633-6. doi: 10.1016/s0960-894x(02)00222-6.

Authors

Yusheng Wu¹, Pierre De Clercq, Maurits Vandewalle, Roger Bouillon, Annemieke Verstuyf

Affiliation

¹ Ghent University, Department of Organic Chemistry, Laboratory for Organic Synthesis, Krijgslaan 281 S4, B-9000 Gent, Belgium.

PMID: 12039579
DOI: 10.1016/s0960-894x(02)00222-6

Abstract

The synthesis and biological properties of seco-C-9,11-bisnor-17-methyl-1 alpha,25-dihydroxyvitamin D(3) novel D-ring analogues are described.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cholecalciferol / analogs & derivatives*
Cholecalciferol / chemical synthesis*
Cholecalciferol / chemistry
Cholecalciferol / pharmacology*
Mice
Receptors, Calcitriol / drug effects
Swine

Substances

C-9,11-bisnor-17-methyl-1, 25-dihydroxyvitamin D3
Receptors, Calcitriol
Cholecalciferol