Drugs, leads, and drug-likeness: an analysis of some recently launched drugs

Bioorg Med Chem Lett. 2002 Jun 17;12(12):1647-50. doi: 10.1016/s0960-894x(02)00244-5.

Abstract

An analysis of the origins of recently launched drugs reveals that most were derived by modification of known drug structures or from lead structures obtained from the scientific literature. High-throughput screening did not have a significant impact on the derivation of these drugs. The drug structures are very closely related to their leads.

MeSH terms

  • Drug Design*
  • Drug Stability
  • Molecular Structure