Drugs, leads, and drug-likeness: an analysis of some recently launched drugs

Bioorg Med Chem Lett. 2002 Jun 17;12(12):1647-50. doi: 10.1016/s0960-894x(02)00244-5.


An analysis of the origins of recently launched drugs reveals that most were derived by modification of known drug structures or from lead structures obtained from the scientific literature. High-throughput screening did not have a significant impact on the derivation of these drugs. The drug structures are very closely related to their leads.

MeSH terms

  • Drug Design*
  • Drug Stability
  • Molecular Structure