Multi-state models for event history analysis

Stat Methods Med Res. 2002 Apr;11(2):91-115. doi: 10.1191/0962280202SM276ra.


An introduction to event history analysis via multi-state models in given. Examples include the two-state model for survival analysis, the competing risks and illness-death models, and models for bone marrow transplantation. Statistical model specification via transition intensities and likelihood inference is introduced. Consequences of observational patterns are discussed, and a real example concerning mortality and bleeding episodes in a liver cirrhosis trial is discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Biometry*
  • Bone Marrow Transplantation / adverse effects
  • Bone Marrow Transplantation / statistics & numerical data
  • Cohort Studies
  • Death
  • Humans
  • Life Change Events*
  • Likelihood Functions
  • Markov Chains
  • Models, Biological*
  • Proportional Hazards Models
  • Regression Analysis
  • Risk
  • Software
  • Survival Analysis