Adenovirus-5 E1A: paradox and paradigm

Nat Rev Mol Cell Biol. 2002 Jun;3(6):441-52. doi: 10.1038/nrm827.


The adenovirus early region 1A (E1A) proteins were described originally as immortalizing oncoproteins that altered transcription in rodent cells. Surprisingly, the 243-amino-acid form of adenovirus-5 E1A was found subsequently to reverse-transform many human tumour cells. Tumour suppression apparently results from the ability of E1A to re-programme transcription in tumour cells, and the molecular basis of this intriguing effect is now beginning to emerge. These discoveries have provided a tool with which to study the regulation of fundamental cellular processes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Adenovirus E1A Proteins / chemistry
  • Adenovirus E1A Proteins / genetics*
  • Adenovirus E1A Proteins / metabolism*
  • Adenoviruses, Human / genetics
  • Adenoviruses, Human / metabolism
  • Amino Acid Sequence
  • Genes, Tumor Suppressor
  • Humans
  • Molecular Sequence Data
  • Oncogenes
  • Retinoblastoma Protein / metabolism


  • Adenovirus E1A Proteins
  • Retinoblastoma Protein